What This Test Measures
The report evaluates all three phases of detoxification, supported by the Detoxification Summary Diagram on page 3, which maps CYP450 enzymes, GST pathways and antiporter activity .
Phase 1: Cytochrome P450 Reactions
These enzymes transform fat soluble chemicals into reactive intermediates ready for clearance
Key genes assessed include:
• CYP1A1, CYP1A2, CYP1B1
• CYP2A6, CYP2C9, CYP2C19, CYP2D6
• CYP2E1 and CYP3A4
- CYP1A1, CYP1A2, CYP1B1
- CYP2A6, CYP2C9, CYP2C19, CYP2D6
- CYP2E1 and CYP3A4
These influence the metabolism of alcohol, medications, environmental pollutants, charred food compounds and mould toxins.
Phase 2: Conjugation Pathways
Phase 2 makes toxins water soluble so they can be excreted.
Your report analyses key pathways such as:
- Glucuronidation: UGT1A1, UGT1A6
- Sulphonation: SULT1A1, SULT1E1, SULT2A1
- Glutathione conjugation: GSTM1, GSTP1, GSTT1
- Acetylation: NAT1, NAT2
- Methylation: COMT, TPMT
These pathways influence the detoxification of hormones, medications, pollutants, inflammatory molecules and oxidative by products.
ROS Detoxification
The report examines your antioxidant defence system which neutralises the free radicals generated during Phase 1.
This includes:
Reduced activity in these genes may increase inflammation and cellular stress.
Phase 3: Antiporter Activity
This final phase moves toxins out of cells for elimination.
The key marker analysed is:
Reduced ABCB1 activity can slow clearance of drugs, lipids and xenobiotics.