Discover the inner workings of your methylation cycle with a comprehensive report, accompanied by a consultation to analyze your results and provide expert recommendations for optimizing your cycle.
Methylation, also referred to as one carbon metabolism, is a process by which methyl groups are added to molecules. It is involved in almost every biochemical reaction in the body, occurring billions of times every second in our cells and contributing to numerous essential bodily functions, including: detoxification, immune function, DNA integrity, regulation of gene expression, energy production, neurotransmitter balance, inflammation control and telomere protection.
Environmental factors such as diet, chemical or drug exposure and stress are known to play a role in supporting or hampering methylation. Important dietary co-factors include B vitamins - B2, B3, B6, B9, B12, methionine, betaine (TMG), choline and S-adenosylmethionine (SAMe).
Insufficiency or deficiency of any of these co-factors may also hinder methylation. Impaired methylation may contribute to major chronic conditions such as fertility issues, fatigue, cardiovascular disorders, neurodegeneration, allergies, anxiety and cancer.
The role of genes in Methylation The purpose of analysing genetic variants (or single nucleotide polymorphisms (SNPs)) in the context of the methylation pathways is to understand the likely effect, such as up or down regulation and subsequent impact on gene function, in order to provide guidance on how to support or bypass weaknesses or bottlenecks.
Although an individual's genetic code cannot be changed, the rate and manner of gene expression, protein synthesis, and function can be supported. This report provides a personalised genotype analysis organised by the following methylation sub-cycles: • The Folate Cycle • The Methionine Cycle • The Transsulphuration Pathway • The BH4 Cycle / Neurotransmitter Metabolism • The Urea Cycle